MovDisordV3, Main, Exploration, bibRecord, 000987

Female reproductive factors, menopausal hormone use, and Parkinson’s disease

Identifieur interne : 000987 ( Main/Exploration ); précédent : 000986; suivant : 000988

Female reproductive factors, menopausal hormone use, and Parkinson’s disease

Auteurs : Rui Liu [États-Unis] ; Donna Baird [États-Unis] ; Yikyung Park [États-Unis] ; Neal D. Freedman [États-Unis] ; Xuemei Huang [États-Unis] ; Albert Hollenbeck [États-Unis] ; Aaron Blair [États-Unis] ; Honglei Chen [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.

RBID : PMC:4057969

English descriptors

KwdEn :
- Aged, Diet, Female, Hormone Replacement Therapy, Humans, Menopause (physiology), Middle Aged, Parkinson Disease (complications), Parkinson Disease (epidemiology), Prospective Studies, Reproduction, Reproductive History, Risk.
MESH :
- complications : Parkinson Disease.
- epidemiology : Parkinson Disease.
- physiology : Menopause.
- Aged, Diet, Female, Hormone Replacement Therapy, Humans, Middle Aged, Prospective Studies, Reproduction, Reproductive History, Risk.

Abstract

Objective

To examine the associations of reproductive factors and exogenous hormone use with risk of Parkinson’s disease (PD) among postmenopausal women.

Methods

The study comprised 119,166 postmenopausal women ages 50–71 years in the NIH-AARP Diet and Health Study, who completed a baseline questionnaire in 1995–1996 and a follow-up survey in 2004–2006. A total of 410 self-reported PD diagnoses were identified between 1995 and 2006. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were derived from logistic regression models.

Results

PD risk was not significantly associated with female reproductive factors including age at menarche, age at first live birth, parity, and age at menopause. For example, compared with women with natural menopause at ages 50–54 years, the ORs were 1.18, (95% CI 0.78–1.79) for women with natural menopause at ages <45, 1.19 (0.88–1.61) for ages 45–49, and 1.33 (0.91–1.93) for ages 55 or later. We found that oral contraceptive use for ≥10 years (vs. never use) was associated with lower PD risk (OR=0.59; 0.38–0.92) but shorter use showed no association. Use of menopausal hormone therapy showed inconsistent results. Compared with non-hormone users at baseline, current hormone users of <5 years showed a higher risk of PD (OR=1.52; 1.11–2.08). However, no associations were observed for past hormone users or current users of ≥5 years.

Conclusions

Overall, this large prospective study provides little support for an association between female reproductive factors and PD risk. Our findings on long-term oral contraceptive use and current hormone therapy warrant further investigations.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057969

DOI: 10.1002/mds.25771
PubMed: 24352877
PubMed Central: 4057969

Affiliations:

Le document en format XML

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<author><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
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<region type="state">District de Columbia</region>
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<author><name sortKey="Blair, Aaron" sort="Blair, Aaron" uniqKey="Blair A" first="Aaron" last="Blair">Aaron Blair</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Epidemiology Branch of the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
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</affiliation>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Diet</term>
<term>Female</term>
<term>Hormone Replacement Therapy</term>
<term>Humans</term>
<term>Menopause (physiology)</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Prospective Studies</term>
<term>Reproduction</term>
<term>Reproductive History</term>
<term>Risk</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Menopause</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Diet</term>
<term>Female</term>
<term>Hormone Replacement Therapy</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Reproduction</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">To examine the associations of reproductive factors and exogenous hormone use with risk of Parkinson’s disease (PD) among postmenopausal women.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">The study comprised 119,166 postmenopausal women ages 50–71 years in the NIH-AARP Diet and Health Study, who completed a baseline questionnaire in 1995–1996 and a follow-up survey in 2004–2006. A total of 410 self-reported PD diagnoses were identified between 1995 and 2006. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were derived from logistic regression models.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">PD risk was not significantly associated with female reproductive factors including age at menarche, age at first live birth, parity, and age at menopause. For example, compared with women with natural menopause at ages 50–54 years, the ORs were 1.18, (95% CI 0.78–1.79) for women with natural menopause at ages <45, 1.19 (0.88–1.61) for ages 45–49, and 1.33 (0.91–1.93) for ages 55 or later. We found that oral contraceptive use for ≥10 years (vs. never use) was associated with lower PD risk (OR=0.59; 0.38–0.92) but shorter use showed no association. Use of menopausal hormone therapy showed inconsistent results. Compared with non-hormone users at baseline, current hormone users of <5 years showed a higher risk of PD (OR=1.52; 1.11–2.08). However, no associations were observed for past hormone users or current users of ≥5 years.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Overall, this large prospective study provides little support for an association between female reproductive factors and PD risk. Our findings on long-term oral contraceptive use and current hormone therapy warrant further investigations.</p>
</sec>
</div>
</front>
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<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
<li>District de Columbia</li>
<li>Maryland</li>
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<settlement><li>Washington (district de Columbia)</li>
</settlement>
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<tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Liu, Rui" sort="Liu, Rui" uniqKey="Liu R" first="Rui" last="Liu">Rui Liu</name>
</region>
<name sortKey="Baird, Donna" sort="Baird, Donna" uniqKey="Baird D" first="Donna" last="Baird">Donna Baird</name>
<name sortKey="Blair, Aaron" sort="Blair, Aaron" uniqKey="Blair A" first="Aaron" last="Blair">Aaron Blair</name>
<name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name>
<name sortKey="Freedman, Neal D" sort="Freedman, Neal D" uniqKey="Freedman N" first="Neal D." last="Freedman">Neal D. Freedman</name>
<name sortKey="Hollenbeck, Albert" sort="Hollenbeck, Albert" uniqKey="Hollenbeck A" first="Albert" last="Hollenbeck">Albert Hollenbeck</name>
<name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
<name sortKey="Park, Yikyung" sort="Park, Yikyung" uniqKey="Park Y" first="Yikyung" last="Park">Yikyung Park</name>
</country>
</tree>
</affiliations>
</record>

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Movement Disorders (revue)

Female reproductive factors, menopausal hormone use, and Parkinson’s disease

Female reproductive factors, menopausal hormone use, and Parkinson’s disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
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